Active-metal template clipping synthesis of novel [2]rotaxanes

We present herein a new synthetic strategy to access [2]rotaxanes, namely active-metal template clipping. We discuss the design of the target [2]rotaxanes, synthesis and characterization of the axle, macrocycle precursors and macrocycles as well as preparation of the final [2]rotaxanes by active template copper(I)-catalyzed alkyne–azide cycloaddition (CuAAC) as key step of the synthesis. HRMS and NMR experiments have been performed to confirm the formation of the interlocked structures.

Beilstein J. Org. Chem. 2023, 19, 1776–1784. doi:10.3762/bjoc.19.130

Source: Beilstein Journal of Organic Chemistry - November 20, 2023 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: active-metal template clipping copper(I)-catalyzed alkyne – azide cycloaddition mechanically interlocked structures [2]rotaxanes Full Research Paper Source Type: research