The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection

The full spectrum of host RNA-binding proteins that control viral infection remains unclear. Tapescu et  al. show that DDX39A binds a conserved RNA structure encoded in the genome of alphaviruses inhibiting infection, independent of the canonical interferon pathway.

Source: Molecular Cell - November 9, 2023 Category: Cytology Authors: Iulia Tapescu, Frances Taschuk, Swechha M. Pokharel, Oleksandr Zginnyk, Max Ferretti, Peter F. Bailer, Kanupryia Whig, Emily A. Madden, Mark T. Heise, David C. Schultz, Sara Cherry Tags: Article Source Type: research