Targeted perturbation of signaling-driven condensates

Gui et  al. propose a model for condensate perturbation through monomer saturation by short interacting peptides. Using β-catenin-binding peptides, they demonstrate that transcriptional condensates can be perturbed, leading to the inhibition of oncogenic WNT signaling. They expand their findings by targe ting the Hippo pathway, demonstrating applicability to other signaling pathways.

Source: Molecular Cell - November 16, 2023 Category: Cytology Authors: Tianshu Gui, Cassio Fleming, Caterina Manzato, Benjamin Bourgeois, Nafiseh Sirati, Jasper Heuer, Ioanna Papadionysiou, Daniel I. van Montfort, Merel van Gijzen, Lydia M.M. Smits, Boudewijn M.T. Burgering, Tobias Madl, Jurian Schuijers Tags: Article Source Type: research