The γ-secretase substrate proteome and its role in cell signaling regulation

The field has been lacking an unbiased approach for large-scale endogenous γ-secretase substrate identification. Hou et al. report a G-SECSI method and demonstrate that the γ-secretase substrate proteome is intimately connected to the intracellular signaling in microglia. γ-Secretase deficiency has profound effects on microglia in response to amyloid pathology.

Source: Molecular Cell - November 16, 2023 Category: Cytology Authors: Pengfei Hou, Magdalena Zielonka, Lutgarde Serneels, Anna Martinez-Muriana, Nicola Fattorelli, Leen Wolfs, Suresh Poovathingal, Dries T'Syen, Sriram Balusu, Tom Theys, Mark Fiers, Renzo Mancuso, Andrew J.M. Howden, Bart De Strooper Tags: Article Source Type: research