Trifluoromethylated hydrazones and acylhydrazones as potent nitrogen-containing fluorinated building blocks

Abstract
Nitrogen-containing organofluorine derivatives, which are prepared using fluorinated building blocks, are among the most important active fragments in various pharmaceutical and agrochemical products. This review focuses on the reactivity, synthesis, and applications of fluoromethylated hydrazones and acylhydrazones. It summarizes recent methodologies that have been used for the synthesis of various nitrogen-containing organofluorine compounds.

Beilstein J. Org. Chem. 2023, 19, 1741–1754. doi:10.3762/bjoc.19.127

Source: Beilstein Journal of Organic Chemistry - November 15, 2023 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: acylhydrazones difluoromethylation dihydropyridazine fluorinated building blocks imidazolidines pyrazoles pyrazolidines pyrazolines trifluoromethylation Review Source Type: research