Genome stability from the perspective of telomere length

Trends Genet. 2023 Nov 11:S0168-9525(23)00241-X. doi: 10.1016/j.tig.2023.10.013. Online ahead of print.ABSTRACTTelomeres and their associated proteins protect the ends of chromosomes to maintain genome stability. Telomeres undergo progressive shortening with each cell division in mammalian somatic cells without telomerase, resulting in genome instability. When telomeres reach a critically short length or are recognized as a damage signal, cells enter a state of senescence, followed by cell cycle arrest, programmed cell death, or immortalization. This review provides an overview of recent advances in the intricate relationship between telomeres and genome instability. Alongside well-established mechanisms such as chromosomal fusion and telomere fusion, we will delve into the perspective on genome stability by examining the role of retrotransposons. Retrotransposons represent an emerging pathway to regulate genome stability through their interactions with telomeres.PMID:37957036 | DOI:10.1016/j.tig.2023.10.013

Source: Trends in Genetics : TIG - November 13, 2023 Category: Genetics & Stem Cells Authors: Xinyi Lu Lin Liu Source Type: research