Reorganization of lamina-associated domains in early mouse embryos is regulated by RNA polymerase II activity [Research Papers]

We report that LADs reorganize gradually in two-cell embryos and that blocking ZGA leads to major changes in nuclear organization, including altered chromatin and genomic features of LADs and redistribution of H3K4me3 toward the nuclear lamina. Our data indicate that the rearrangement of LADs is an integral component of the maternal-to-zygotic transition and that transcription contributes to shaping nuclear organization at the beginning of mammalian development.

Source: Genes and Development - November 13, 2023 Category: Genetics & Stem Cells Authors: Pal, M., Altamirano-Pacheco, L., Schauer, T., Torres-Padilla, M.-E. Tags: Research Papers Source Type: research