Harvesting phosphorus-containing moieties for their antibacterial effects

Bioorg Med Chem. 2023 Nov 2;96:117512. doi: 10.1016/j.bmc.2023.117512. Online ahead of print.ABSTRACTClinically manifested resistance of bacteria to antibiotics has emerged as a global threat to society and there is an urgent need for the development of novel classes of antibacterial agents. Recently, the use of phosphorus in antibacterial agents has been explored in quite an unprecedent manner. In this comprehensive review, we summarize the use of phosphorus-containing moieties (phosphonates, phosphonamidates, phosphonopeptides, phosphates, phosphoramidates, phosphinates, phosphine oxides, and phosphoniums) in compounds with antibacterial effect, including their use as β-lactamase inhibitors and antibacterial disinfectants. We show that phosphorus-containing moieties can serve as novel pharmacophores, bioisosteres, and prodrugs to modify pharmacodynamic and pharmacokinetic properties. We further discuss the mechanisms of action, biological activities, clinical use and highlight possible future prospects.PMID:37939493 | DOI:10.1016/j.bmc.2023.117512

Source: Bioorganic and Medicinal Chemistry - November 8, 2023 Category: Chemistry Authors: Manuela Vor áčová Matej Zore Jari Yli-Kauhaluoma Paula Kiuru Source Type: research