Key indices of glycaemic variability for application in diabetes clinical practice

Diabetes Metab. 2023 Oct 24:101488. doi: 10.1016/j.diabet.2023.101488. Online ahead of print.ABSTRACTNear normal glycaemic control in diabetes consists to target daily glucose fluctuations and quarterly HbA1c oscillations in addition to overall glucose exposure. Consequently, the prerequisite is to define simple, and mathematically undisputable key metrics for the short- and long-term variability in glucose homeostasis. As the standard deviations (SD) of either glucose or HbA1c are dependent on their means, the coefficient of variation (CV = SD/mean) should be applied instead as it that avoids the correlation between the SD and mean values, A CV glucose of 36% is the most appropriate threshold between those with stable versus labile glucose homeostasis. However, when near normal mean glucose concentrations are achieved a lower CV threshold of < 27% is necessary for reducing the risk for hypoglycaemia to a minimal rate. For the long-term variability in glucose homeostasis, a CVHbA1c < 5% seems to be a relevant recommendation for preventing adverse clinical outcomes.PMID:37884123 | DOI:10.1016/j.diabet.2023.101488

Source: Diabetes and Metabolism - October 26, 2023 Category: Endocrinology Authors: Louis Monnier Fabrice Bonnet Claude Colette Eric Renard David Owens Source Type: research