Chromatin bridges: stochastic breakage or regulated resolution?

Trends Genet. 2023 Oct 25:S0168-9525(23)00232-9. doi: 10.1016/j.tig.2023.10.004. Online ahead of print.ABSTRACTGenetic material is organized in the form of chromosomes, which need to be segregated accurately into two daughter cells in each cell cycle. However, chromosome fusion or the presence of unresolved interchromosomal linkages lead to the formation of chromatin bridges, which can induce DNA lesions and genome instability. Persistent chromatin bridges are trapped in the cleavage furrow and are broken at or after abscission, the final step of cytokinesis. In this review, we focus on recent progress in understanding the mechanism of bridge breakage and resolution. We discuss the molecular machinery and enzymes that have been implicated in the breakage and processing of bridge DNA. In addition, we outline both the immediate outcomes and genomic consequences induced by bridge breakage.PMID:37891096 | DOI:10.1016/j.tig.2023.10.004

Source: Trends in Genetics : TIG - October 27, 2023 Category: Genetics & Stem Cells Authors: Huadong Jiang Ying Wai Chan Source Type: research