Lactate activates the mitochondrial electron transport chain independently of its metabolism

Cai et  al. found that lactate serves as a mitochondrial messenger that stimulates the electron transport chain independent of its metabolism. Lactate shifts ATP production from glycolysis to oxidative phosphorylation, allowing cells to conserve glucose while using lactate-derived pyruvate as their prefer ential substrate to support cellular ATP production.

Source: Molecular Cell - October 24, 2023 Category: Cytology Authors: Xin Cai, Charles P. Ng, Olivia Jones, Tak Shun Fung, Keun Woo Ryu, Dayi Li, Craig B. Thompson Tags: Article Source Type: research