Human histone H1 variants impact splicing outcome by controlling RNA polymerase II elongation

Pascal et  al. characterized genomic binding profiles of six H1 variants by creating cell lines lacking up to five H1 subtypes. Most H1s bind to specific sites, influenced by factors like GC content. H1 histones regulate mRNA splicing by modulating the elongation rate of RNA polymerase II.

Source: Molecular Cell - November 2, 2023 Category: Cytology Authors: Corina Pascal, Jonathan Zonszain, Ofir Hameiri, Chen Gargi-Levi, Galit Lev-Maor, Luna Tammer, Tamar Levy, Anan Tarabeih, Vanessa Rachel Roy, Stav Ben-Salmon, Liraz Elbaz, Mireille Eid, Tamar Hakim, Salima Abu Rabe'a, Nana Shalev, Albert Jordan, Eran Mesho Tags: Article Source Type: research