A tale of two pathways: Two distinct mechanisms of ADAR1 prevent fatal autoinflammation

In this issue, Hu and Heraud-Farlow et  al.1 demonstrate that ADAR1 dsRNA editing and dsRNA binding activities are critical to repress MDA5 and PKR, respectively, and that PKR and MDA5 act in concert to induce fatality in ADAR1 KO mice.

Source: Molecular Cell - November 2, 2023 Category: Cytology Authors: Tyler J. Dorrity, Hachung Chung Tags: Preview Source Type: research