Brodalumab for severe hidradenitis suppurativa: a case of clinico-radiologic improvement and literature review

We report the case of a 50-year-old man with long-standing HS and concomitant palmo-plantar psoriasis treated with brodalumab after failure of various TNF-α inhibitors. The HS lesions and the patient's quality of life improved steadily over time until week-136. Interestingly, the clinical benefit was confirmed by radiological improvement with MRI evaluation. Our case report demonstrates the long-term efficacy and safety of brodalumab in HS encouraging the use of drugs to inhibit the T helper-type 17 immune axis, especially in cases of HS refractory to therapy with TNF-α inhibitors.PMID:37842732 | DOI:10.1080/09546634.2023.2270091
Source: Journal of Dermatological Treatment - Category: Dermatology Authors: Source Type: research