Hallmarks of the metabolic secretome

Trends Endocrinol Metab. 2023 Oct 14:S1043-2760(23)00195-9. doi: 10.1016/j.tem.2023.09.006. Online ahead of print.ABSTRACTThe identification of novel secreted factors is advancing at an unprecedented pace. However, there is a critical need to consolidate and integrate this knowledge to provide a framework of their diverse mechanisms, functional significance, and inter-relationships. Complicating this effort are challenges related to nonstandardized methods, discrepancies in sample handling, and inconsistencies in the annotation of unknown molecules. This Review aims to synthesize the rapidly expanding field of the metabolic secretome, encompassing the five major types of secreted factors: proteins, peptides, metabolites, lipids, and extracellular vesicles. By systematically defining the functions and detection of the components within the metabolic secretome, this Review provides a primer into the advances of the field, and how integration of the techniques discussed can provide a deeper understanding of the mechanisms underlying metabolic homeostasis and its disorders.PMID:37845120 | DOI:10.1016/j.tem.2023.09.006

Source: Trends in Endocrinology and Metabolism: TEM - October 16, 2023 Category: Endocrinology Authors: Saranya C Reghupaty Nicholas R Dall Katrin J Svensson Source Type: research