The Role of Endothelial Cells in Atherosclerosis

Endothelial cells (ECs) mediate several biological functions that are relevant to atherosclerosis and coronary artery disease (CAD), regulating an array of vital processes including vascular tone, wound healing, reactive oxygen species, shear stress response, and inflammation. Although it is not yet known which of these functions is linked causally with CAD development and/or progression, genome-wide association studies have implicated more than 400 loci associated with CAD risk, among which several have shown EC-relevant functions.

Source: American Journal of Pathology - October 9, 2023 Category: Pathology Authors: Mark E. Pepin, Rajat Gupta Tags: Review Source Type: research