Selective BET inhibitor RVX-208 ameliorates periodontal inflammation and bone loss

CONCLUSIONS: RVX-208 regulated both upstream (inflammatory cytokine production) and downstream (osteoclast differentiation) events that lead to periodontal tissue destruction, suggesting that it may be a promising 'epi-drug' for the prevention of periodontitis.PMID:37855275 | DOI:10.1111/jcpe.13887

Source: Journal of Clinical Periodontology - October 19, 2023 Category: Dentistry Authors: Mingxu Sun Nicholas Clayton Sheikh Alam Niels Asmussen Andrew Wong Jin Ha Kim Gary Luong Sasan Mokhtari David Pellei Caroline K Carrico Zvi Schwartz Barbara D Boyan William V Giannobile Sinem Esra Sahingur Zhao Lin Source Type: research