DICER ribonuclease removes harmful R-loops

R-loops, consisting of a DNA-RNA hybrid and a displaced DNA strand, can compromise genome integrity. Thus far, only type H RNases are known to cleave RNA within DNA-RNA hybrids and R-loops. Camino and Dutta et  al. show that DICER RNase cleaves RNA within the context of R-loops.

Source: Molecular Cell - October 11, 2023 Category: Cytology Authors: Lola P. Camino, Arijit Dutta, Sonia Barroso, Carmen P érez-Calero, Jeffrey N. Katz, María García-Rubio, Patrick Sung, Belén Gómez-González, Andrés Aguilera Tags: Article Source Type: research