DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C

Homologous-recombination-deficient (HRD) tumors often develop resistance to traditional chemotherapies, making them difficult to kill. Kovacs et  al. find that HRD tumor cells exhibit DNA-damage-induced nuclear envelope (NE) rupture and subsequent NE vulnerability. Targeting this structural vulnerability could potentially provide a complement to traditional, DNA-damage-based chemotherapies.

Source: Molecular Cell - October 12, 2023 Category: Cytology Authors: Marton Tibor Kovacs, Marie Vallette, Pauline Wiertsema, Florent Dingli, Damarys Loew, Guilherme Pedreira de Freitas Nader, Matthieu Piel, Raphael Ceccaldi Tags: Article Source Type: research