ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei

Joo et  al. uncover a surprising role for ATR in promoting rupture of micronuclei (MN). ATR phosphorylates Lamin A/C at S395 and primes S392 for CDK1 phosphorylation, destabilizing the MN envelope. ATR-driven MN rupture activates cGAS and downstream cell-autonomous and cell-non-autonomous processes, prote cting genomic integrity in cell populations.

Source: Molecular Cell - October 2, 2023 Category: Cytology Authors: Yoon Ki Joo, Elizabeth M. Black, Isabelle Trier, Wisse Haakma, Lee Zou, Lilian Kabeche Tags: Article Source Type: research