Decagram-Scale Synthesis of N-{2-[4-( β-d-Glucopyranosyloxy)-2-methylphenyl]-1,1-dimethyl-2-oxoethyl}-3-methylthiophene-2-carboxamide (GPTC), a Metabolite of the Fungicide Isofetamid

Synlett DOI: 10.1055/a-2178-1442 A decagram-scale synthesis of N-{2-[4-(β-d-glucopyranosyloxy)-2-methylphenyl]-1,1-dimethyl-2-oxoethyl}-3-methylthiophene-2-carboxamide (GPTC), a metabolite of the fungicide isofetamid, has been achieved in a highly straightforward manner from the known compound 1-(4-hydroxy-2-methylphenyl)-2-methylpropan-1-one in eight steps with a 20% overall yield to provide a standard certified reference material for residue analysis in food. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - October 17, 2023 Category: Chemistry Authors: Jang, Hongjun Kwak, Soo Yeon Kim, Young Hoon Han, Jae-hyuk Park, Youngjik Baek, Seung-Hoon Lee, Dongjoo Kim, Hyoungsu Tags: letter Source Type: research