Periodic generalized edema following COVID-19 infection

Am J Med Sci. 2023 Oct 8:S0002-9629(23)01371-X. doi: 10.1016/j.amjms.2023.10.002. Online ahead of print.ABSTRACTThe unprecedented impact and sequelae of COVID-19 infection are not yet fully understood, and better understanding of the pathophysiology of these infections is needed. Endothelial dysfunction might be common sequelae associated with COVID-19, and increased inflammatory responses, oxidative stress, proinflammatory cytokines, and impaired mitochondrial function also contribute to the pathophysiology of post COVID-19 medical disorders. Systemic capillary leak syndrome following COVID-19 infection, both new onset and exacerbation of a prior disorder, has been reported. The pathophysiology of SCLS is uncertain; it likely develops during transient vascular endothelial dysfunction or endotheliopathy and inflammation resulting from circulating humoral factors. Here, we report a case of adult patient with 2 episodes of systemic capillary leak syndrome following prior COVID-19 infection. This patient had a transient response to intravenous IgG.PMID:37816456 | DOI:10.1016/j.amjms.2023.10.002

Source: The American Journal of the Medical Sciences - October 10, 2023 Category: General Medicine Authors: Arunee Motes Kenneth Nugent Source Type: research