Ablation of integrin-mediated cell-collagen communication alleviates fibrosis

Conclusions
The data provide evidence for a crucial role of collagen-binding integrins in fibroblast force generation and differentiation in vitro and for matrix deposition and tissue remodelling in vivo. Targeting fibroblast–collagen interactions might represent a promising therapeutic approach to regulate connective tissue deposition in fibrotic diseases.

Source: Annals of the Rheumatic Diseases - October 12, 2023 Category: Rheumatology Authors: Sawant, M., Wang, F., Koester, J., Niehoff, A., Nava, M. M., Lundgren-Akerlund, E., Gullberg, D., Leitinger, B., Wickström, S., Eckes, B., Krieg, T. Tags: ARD, Miscellaneous Source Type: research