Nickel-Catalyzed Decarbonylation of α-Oxyacetic Acid Thioesters: Hydroxymethylation of Mercaptans

Synlett DOI: 10.1055/a-2159-4369 A strategy for the Ni-catalyzed decarbonylation of α-oxyacetic acid thioesters is described, providing a new pathway for the synthesis of monosulfide acetals, and further proving that oxygen atoms can stabilize an α-carbocation and promote a decarbonylation reaction. This method has good functional-group compatibility and can tolerate a wide range of electron-withdrawing, electron-neutral, and electron-donating substituents. In addition, this method complements the conventional cross-coupling reactions. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - October 11, 2023 Category: Chemistry Authors: Tian, Rui Li, Jia-Xin Zhu, Yong-Ming Tags: letter Source Type: research