Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy

Fan et  al. report that cGAS undergoes ZDHHC9-mediated palmitoylation to promote its activation, which is antagonized by the acyl-protein thioesterase LYPLAL1. Furthermore, they provide a strategy to augment the cGAS-mediated anti-viral as well as anti-tumor immunity by inhibiting LYPLAL1.

Source: Molecular Cell - October 5, 2023 Category: Cytology Authors: Yizeng Fan, Yang Gao, Li Nie, Tao Hou, Weichao Dan, Zixi Wang, Tianjie Liu, Yi Wei, Yuzhao Wang, Bo Liu, Taotao Que, Yuzeshi Lei, Jin Zeng, Jian Ma, Wenyi Wei, Lei Li Tags: Article Source Type: research