S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy

How autophagosomes efficiently sequester phase-separated p62 droplets remains unclear. Huang et  al. found a posttranslational modification of p62 with long-chain fatty acids. p62 S-acylation regulates p62 droplet recruitment to the autophagic membrane and selective autophagic flux, thereby contributing to the control of selective autophagic clearance of ubiquitinated proteins.

Source: Molecular Cell - October 5, 2023 Category: Cytology Authors: Xue Huang, Jia Yao, Lu Liu, Jing Chen, Ligang Mei, Jingjing Huangfu, Dong Luo, Xinyi Wang, Changhai Lin, Xiaorong Chen, Yi Yang, Sheng Ouyang, Fujing Wei, Zhuolin Wang, Shaolin Zhang, Tingxiu Xiang, Dante Neculai, Qiming Sun, Eryan Kong, Edward W. Tate, A Tags: Article Source Type: research