Metal-Free Catalyzed Defluorinative O-Arylation of Pyrazolones with Polyfluoroarenes

Synlett DOI: 10.1055/a-2158-1015 An efficient and general method for defluorinative O-arylation of pyrazolones has been successfully developed under metal-free conditions. This methodology allows for the synthesis of desired products by using a wide range of pyrazolones and polyfluoroarenes as starting materials. The compatibility of various substrates was demonstrated, ensuring the applicability of this method. Furthermore, the synthesis of the target compounds at a gram scale and the ability to perform late-stage modifications highlight the potential of this approach in preparative pharmaceutical synthesis and organofluorine chemistry. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - September 27, 2023 Category: Chemistry Authors: Yang, Liu Qin, Tao Liu, Bin Tags: letter Source Type: research