A methodological review of Population-Adjusted Indirect Comparisons reveals inconsistent reporting and suggests publication bias

Population-adjusted indirect comparisons (PAICs) were developed in the 2010s to allow for comparisons between two treatments evaluated in different trials while accounting for differences in patient characteristics if individual patient data (IPD) are available for only one trial. Such comparisons are increasingly used in market access applications when a pharmaceutical company compares its new treatment (with IPD available) to another treatment developed by a competitor (with only aggregated data available).

Source: Journal of Clinical Epidemiology - September 15, 2023 Category: Epidemiology Authors: Arnaud Serret-Larmande, Belkacem Zenati, Agn ès Dechartres, Jérôme Lambert, David Hajage Tags: Original Article Source Type: research