Gut microbiota as non-invasive diagnostic and prognostic biomarkers for natural killer/T-cell lymphoma

We read with interest the study by Kartal et al1 showing that the gut-microbiota-derived biomarkers for disease stratification are often shared by subjects across disease cohorts. Here, we confirmed their observations with findings from a newly diagnosed natural killer/T-cell lymphoma (NKTCL) cohort, in which the gut biomarkers were significantly overlapped with those of multiple disease cohorts and consistently enriched/depleted in subjects with those diseases. Importantly, many of the shared biomarkers were remarkably associated with patient outcomes in our cohort, implying that they may have broad prognostic values in multiple diseases. ‘Microbiota-gut-lymphoma axis’ represents a fascinating avenue of microbiota-mediated lymphomagenesis and intervention opportunity,2 but the implications of gut microbiota in NKTCL remain enigmatic. To identify gut microbiota-derived diagnostic biomarkers for NKTCL, we recruited a discovery cohort consisting of 30 treatment-naïve patients and 20 healthy controls (HCs), and a validation cohort, including 12 patients and 13 HCs,...

Source: Gut - September 13, 2023 Category: Gastroenterology Authors: Shi, Z., Hu, G., Li, M. W., Zhang, L., Li, X., Li, L., Wang, X., Fu, X., Sun, Z., Zhang, X., Tian, L., Li, Z., Chen, W.-H., Zhang, M. Tags: Open access, Gut PostScript Source Type: research