A Concise and Flexible Synthesis of C2 ′-Sulfonylated Quinine Derivatives

Synthesis DOI: 10.1055/a-2135-9037 A concise and flexible procedure for the synthesis of structurally novel C2′-sulfonylated quinine derivatives is developed. Through careful optimization of the reaction conditions, most of the reactions can be performed in high yields at gram or several hundreds of milligram scale. Since cinchona-based derivatives are widely used in asymmetric catalysis, the synthetic route developed herein provides an efficient and practical pathway for the diverse synthesis of new cinchona derivatives as potential chiral ligands or multifunctional organocatalysts. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synthesis - September 7, 2023 Category: Chemistry Authors: Gu, Cheng-Yu Zhou, Jie Tan, Dong-Xing Han, Fu-She Tags: paper Source Type: research