Subtelomeres: hotspots of genome variation

Genes Genet Syst. 2023 Aug 30. doi: 10.1266/ggs.23-00049. Online ahead of print.ABSTRACTEukaryotic cells contain multiple types of duplicated sequences. Typical examples are tandem repeat sequences including telomeres, centromeres, rDNA genes and transposable elements. Most of these sequences are unstable; thus, their copy numbers or sequences change rapidly in the course of evolution. In this review, I will describe roles of subtelomere regions, which are located adjacent to telomeres at chromosome ends, and recent discoveries about their sequence variation.PMID:37648502 | DOI:10.1266/ggs.23-00049

Source: Genes and Genetic Systems - August 30, 2023 Category: Genetics & Stem Cells Authors: Junko Kanoh Source Type: research