Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation

Chronic inflammation causes a high burden of disability and mortality worldwide. Vascular macrophages are key orchestrators of homeostasis and vice versa of chronic inflammation. Pekayvaz et  al. show how mural cells (the contractile cells of the vessel wall) actively sustain the vascular macrophage niche and keep it in a functional state.

Source: Immunity - August 30, 2023 Category: Allergy & Immunology Authors: Kami Pekayvaz, Christoph Gold, Parandis Hoseinpour, Anouk Engel, Alejandro Martinez-Navarro, Luke Eivers, Raffaele Coletti, Markus Joppich, Fl ávio Dionísio, Rainer Kaiser, Lukas Tomas, Aleksandar Janjic, Maximilian Knott, Fitsumbirhan Mehari, Vivien Po Tags: Article Source Type: research