Mechanotransduction via endothelial adhesion molecule CD31 initiates transmigration and reveals a role for VEGFR2 in diapedesis

Interaction between leukocyte PECAM and endothelial cell PECAM is known to initiate transendothelial migration (TEM), but how these interactions result in TEM is not known. Fu and Sullivan et  al. show that physical tension across endothelial PECAM in a complex with VE-cadherin and VEGFR2 transduces this signal and, in doing so, demonstrates a role for VEGFR2 in TEM.

Source: Immunity - August 28, 2023 Category: Allergy & Immunology Authors: Tao Fu, David P. Sullivan, Annette M. Gonzalez, Maureen E. Haynes, Prarthana J. Dalal, Nakisha S. Rutledge, Abigail L. Tierney, Julia A. Yescas, Evan W. Weber, William A. Muller Tags: Article Source Type: research