Circulating IRF8-expressing CD123 < sup > + < /sup > CD127 < sup > + < /sup > lymphoid progenitors: key players in human hematopoiesis

Trends Immunol. 2023 Aug 15:S1471-4906(23)00138-2. doi: 10.1016/j.it.2023.07.004. Online ahead of print.ABSTRACTLymphopoiesis is the process in which B and T cells, and innate lymphoid cells (ILCs) develop from hematopoietic progenitors that exhibit early lymphoid priming. The branching points where lymphoid-primed human progenitors are further specified to B/T/ILC differentiation trajectories remain unclear. Here, we discuss the emerging role of interferon regulatory factor (IRF)8 as a key factor to bridge human lymphoid and dendritic cell (DC) differentiation, and the current evidence for the existence of circulating and tissue-resident CD123+CD127+ lymphoid progenitors. We propose a model whereby DC/B/T/ILC lineage programs in circulating CD123+CD127+ lymphoid progenitors are expressed in balance. Upon tissue seeding, the tissue microenvironment tilts this molecular balance towards a specific lineage, thereby determining in vivo lineage fates. Finally, we discuss the translational implication of these lymphoid precursors.PMID:37591714 | DOI:10.1016/j.it.2023.07.004
Source: Trends in Immunology - Category: Allergy & Immunology Authors: Source Type: research