How Pol α-primase is targeted to replisomes to prime eukaryotic DNA replication

By determining cryo-EM structures of budding yeast and human replisomes containing the Pol α-primase complex, Jones et al. reveal a conserved mechanism for the coordination of nascent-strand priming in the eukaryotic replisome. The mechanism explains why priming by Pol α-primase is highly efficient on the lagging-strand but not leading-strand template.

Source: Molecular Cell - July 27, 2023 Category: Cytology Authors: Morgan L. Jones, Valentina Aria, Yasemin Baris, Joseph T.P. Yeeles Tags: Article Source Type: research