Multi-ancestry GWAS analysis identifies two novel loci associated with diabetic eye disease and highlights < i > APOL1 < /i > as a high risk locus in patients with diabetic macular edema

by Amy D. Stockwell, Michael C. Chang, Anubha Mahajan, William Forrest, Neha Anegondi, Rion K. Pendergrass, Suresh Selvaraj, Jens Reeder, Eric Wei, VA Iglesias, Natalie M. Creps, Laura Macri, Andrea N. Neeranjan, Marcel P. van der Brug, Suzie J. Scales, Mark I. McCarthy, Brian L. Yaspan Diabetic retinopathy (DR) is a common complication of diabetes. Approximately 20% of DR patients have diabetic macular edema (DME) characterized by fluid leakage into the retina. There is a genetic component to DR and DME risk, but few replicable loci. Because not all DR cases have DME, we focused on DME to increase power, and conducted a multi-ancestry GWAS to assess DME risk in a total of 1,502 DME patients and 5,603 non-DME controls in discovery and replication datasets. Two loci reached GWAS significance (p
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research