Characterization of behavioral changes in T-maze alternation from dopamine D1 agonists with different receptor coupling mechanisms

ConclusionsThese data suggest that D1 signaling bias in these two pathways (cAMP vs β-arrestin) has complex effects on cognitive processes as assessed by T-maze alternation. Understanding these mechanisms should allow the identification or discovery of D1 agonists that can provide superior cognitive enhancement.

Source: Psychopharmacology - August 14, 2023 Category: Psychiatry Source Type: research