Synthesis of Quinoline and Quinolin-2(1H)-one Derivatives via Nickel Boride Promoted Reductive Cyclization

Synthesis DOI: 10.1055/a-2116-5206 A mild and efficient approach for the synthesis of diversely substituted quinoline and quinolin-2-one derivatives is disclosed. In situ generated nickel boride proved to be an effective promoter of the reductive cyclization reaction. Broad substrate scope, mild reaction conditions, consistent yield, and a wide range of functional group tolerance are the other notable features of the newly discovered reaction. A large number of quinoline and quinolin-2-one derivatives may be prepared from milligram to multigram scale employing this intramolecular reductive cyclization protocol. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synthesis - August 7, 2023 Category: Chemistry Authors: Sarkar, Rumpa Samanta, Surya Kanta Menon, Anila M. Chopra, Deepak Ganguly, Debabani Bera, Mrinal K. Tags: paper Source Type: research