FUBP1 is a general splicing factor facilitating 3 ′ splice site recognition and splicing of long introns

Ebersberger et  al. identify the RNA-binding protein FUBP1 as a key splicing factor that binds to a hitherto unknown cis-regulatory motif at 3′ splice sites. Multivalent interactions of FUBP1 with splice site components support spliceosome assembly at multiple stages and ensure efficient splicing of long intron s.

Source: Molecular Cell - July 27, 2023 Category: Cytology Authors: Stefanie Ebersberger, Clara Hipp, Miriam M. Mulorz, Andreas Buchbender, Dalmira Hubrich, Hyun-Seo Kang, Santiago Mart ínez-Lumbreras, Panajot Kristofori, F.X. Reymond Sutandy, Lidia Llacsahuanga Allcca, Jonas Schönfeld, Cem Bakisoglu, Anke Busch, Heike Tags: Article Source Type: research