NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation

Red blood cell rupture (hemolysis) activates innate immunity and inflammation by releasing heme. Sundaram et  al.1 implicate the immune sensor NLRP12 in hemolytic disease, showing that it controls necrotic cell death induction in response to heme combined with pathogen-associated molecules.

Source: Molecular Cell - August 3, 2023 Category: Cytology Authors: Elliott M. Bernard, Petr Broz Tags: Spotlight Source Type: research