Recurrent Stroke with Rapid Development of Intracranial Artery Stenosis and Subsequent Successful Mechanical Thrombectomy in Essential Thrombocythemia

Intern Med. 2023 Jul 26. doi: 10.2169/internalmedicine.2189-23. Online ahead of print.ABSTRACTEssential thrombocythemia is a myeloproliferative neoplasm. Ischemic stroke is frequently the first manifestation of essential thrombocythemia. We herein report a patient with JAK2V617 mutation-positive essential thrombocythemia who developed recurrent ischemic stroke with rapid development of intracranial artery stenosis and subsequently underwent successful mechanical thrombectomy. The high JAK2V617F allele burden in our patient (58.4%) may have affected the patient's condition. We discuss similar reports in the literature and the possible pathophysiologic mechanism of large artery involvement in these patients.PMID:37495531 | DOI:10.2169/internalmedicine.2189-23

Source: Internal Medicine - July 26, 2023 Category: Internal Medicine Authors: Yuji Kato Shohei Iijima Shinya Kohyama Tomoya Maeda Tsugumi Sato Shinichi Takahashi Satoshi Suda Source Type: research