Titanium-Catalyzed Intermolecular Hydroaminoalkylation of Terminal Alkynes

Synthesis DOI: 10.1055/a-2111-9910 Terminal alkynes undergo intermolecular hydroaminoalkylation reactions with secondary amines in the presence of titanium catalysts and depending on the catalyst and the structure of the substrates, allylic amines and/or imines are formed as products in moderate yields. In addition, the desired allylamines can also be obtained from a convenient reaction sequence consisting of an initial hydroaminoalkylation of trimethylsilyl-protected alkynes and a subsequent protodesilylation that selectively delivers γ-unsubstituted allylamines. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synthesis - July 27, 2023 Category: Chemistry Authors: Thye, Hermann Fornfeist, Felix Geik, Dennis Schl üschen, Levi L. Schmidtmann, Marc Doye, Sven Tags: feature Source Type: research