Dendritic cell type 3 arises from Ly6C+ monocyte-dendritic cell progenitors

Delineating the lineage development of dendritic cells (DCs) is challenging as these cells show overlapping phenotypes with monocytes and other cells. Using single-cell sequencing and fate mapping approaches, Liu et  al. demonstrate that murine DCs develop through three lineages, with DC3s developing from Ly6C+ monocyte-dendritic cell progenitors (MDPs) through pro-DC3s.

Source: Immunity - July 27, 2023 Category: Allergy & Immunology Authors: Zhaoyuan Liu, Haiting Wang, Ziyi Li, Regine J. Dress, Yiwen Zhu, Shuangyan Zhang, Donatella De Feo, Wan Ting Kong, Peiliang Cai, Amanda Shin, C écile Piot, Jiangyan Yu, Yaqi Gu, Mingnan Zhang, Caixia Gao, Lei Chen, Honglin Wang, Mathias Vétillard, Pierr Tags: Article Source Type: research