Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks

Conventional dendritic cells (cDCs) are short-lived cells, being constantly replaced by precursors (preDCs) from the bone marrow. Ugur et  al. provide insight into the niches that maintain these cells, showing that preDCs home to the LN medulla and generate a network that extends toward the paracortex. Inflammation promotes rapid maturation of cDC1s, leaving gaps in this network that are filled by local Flt3L feedback.

Source: Immunity - July 17, 2023 Category: Allergy & Immunology Authors: Milas Ugur, R. Jacob Labios, Chloe Fenton, Konrad Kn öpper, Katarzyna Jobin, Fabian Imdahl, Gosia Golda, Kathrin Hoh, Anika Grafen, Tsuneyasu Kaisho, Antoine-Emmanuel Saliba, Dominic Grün, Georg Gasteiger, Marc Bajénoff, Wolfgang Kastenmüller Tags: Article Source Type: research