Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression

Glioblastoma is notorious for immunosuppression, but the mechanisms are unclear. Sattiraju et  al. report that hypoxic zones in GBM attract and sequester tumor-associated myeloid cells and cytotoxic T cells, where they are reprogrammed into an immunosuppressive state. This process is influenced by the immunocompetence state of the host and involves CCL8 and IL-1B as niche factors in hypoxi c zones.

Source: Immunity - July 13, 2023 Category: Allergy & Immunology Authors: Anirudh Sattiraju, Sangjo Kang, Bruno Giotti, Zhihong Chen, Valerie J. Marallano, Concetta Brusco, Aarthi Ramakrishnan, Li Shen, Alexander M. Tsankov, Dolores Hambardzumyan, Roland H. Friedel, Hongyan Zou Tags: Article Source Type: research