Mammalian aging driven by transcription going awry

Trends Genet. 2023 Jul 5:S0168-9525(23)00137-3. doi: 10.1016/j.tig.2023.06.006. Online ahead of print.ABSTRACTThe mechanisms that underlie increased cryptic transcription during senescence and aging have been poorly understood. Sen et al. recently identified cryptic transcription start sites (cTSSs) and chromatin state changes that may contribute to cTSS activation in mammals. Their results indicate that enhancer-promoter conversion may drive cryptic transcription in senescence.PMID:37419698 | DOI:10.1016/j.tig.2023.06.006

Source: Trends in Genetics : TIG - July 7, 2023 Category: Genetics & Stem Cells Authors: Brenna S McCauley Weiwei Dang Source Type: research