Stress and Liver Fibrogenesis: Understanding the role and regulation of stress response pathways in Hepatic Stellate Cells

Stress response pathways are crucial for cells to adapt to physiological and pathological conditions. Increased transcription and translation in response to stimuli places a strain on the cell, necessitating increased amino acid supply, protein production and folding, and disposal of misfolded proteins. Stress response pathways such as the Unfolded Protein Response (UPR) and the Integrated Stress Response (ISR) allow cells to adapt to stress and restore homeostasis; however, their role and regulation in pathological conditions such as hepatic fibrogenesis are unclear.

Source: American Journal of Pathology - July 6, 2023 Category: Pathology Authors: Zachary Hanquier, Jagannath Misra, Reese Baxter, Jessica L. Maiers Tags: Review Source Type: research