Centromere/kinetochore is assembled through CENP-C oligomerization

Hara et  al. find that CENP-C, a centromeric protein, is oligomerized through the Cupin domain in its C-terminal region. The oligomerization of the Cupin domain is essential for CENP-C function to localize CCAN proteins to centromeres and assemble kinetochore and centromeric chromatin.

Source: Molecular Cell - June 8, 2023 Category: Cytology Authors: Masatoshi Hara, Mariko Ariyoshi, Tomoki Sano, Ryu-Suke Nozawa, Soya Shinkai, Shuichi Onami, Isabelle Jansen, Toru Hirota, Tatsuo Fukagawa Tags: Article Source Type: research