Fractionation Approaches in Whole Breast RT

AbstractPurpose of ReviewTo review the current approaches to fractionation from phase III prospective randomized trials for postlumpectomy whole breast radiation therapy (WBRT) for early-stage breast cancer.Recent FindingsModerate hypofractionation (M-WBRT) given Monday through Friday over 3 –4 weeks is now standard practice for almost all patients needing postlumpectomy WBRT. The use of M-WBRT is being expanded to include regional node irradiation (RNI) and may be further shortened by a tumor bed boost that is concurrent rather than sequential to avoid extra days of treatment. And f or selected patients, there is now an option for ultra-hypofractionation (U-WBRT) that further shortens WBRT to as few as 5 treatments in 1 week.SummaryWhen WBRT is indicated after lumpectomy for early-stage breast cancer, moderate hypofractionation over 3  weeks is the preferred radiation schedule for most patients. Select patients are eligible for a 1-week schedule using ultra-hypofractionation.
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research