Aromatic C – H bond functionalization through organocatalyzed asymmetric intermolecular aza-Friedel – Crafts reaction: a recent update

Abstract
The aza-Friedel–Crafts reaction allows an efficient coupling of electron-rich aromatic systems with imines for the facile incorporation of aminoalkyl groups into the aromatic ring. This reaction has a great scope of forming aza-stereocenters which can be tuned by different asymmetric catalysts. This review assembles recent advances in asymmetric aza-Friedel–Crafts reactions mediated by organocatalysts. The mechanistic interpretation with the origin of stereoselectivity is also explained.

Beilstein J. Org. Chem. 2023, 19, 956–981. doi:10.3762/bjoc.19.72

Source: Beilstein Journal of Organic Chemistry - June 28, 2023 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: asymmetric aza-Friedel – Crafts reaction H-bonding organocatalysis stereoselectivity Review Source Type: research